Fig. 3.

Metformin binding site in SLC22A2 protein. A, B and C. Metformin binding site in SLC22A2 270A variant. E, F and G. Metformin binding site in SLC22A2 270S variant. Solid arrows (matched colour) denote reference points to compare structures. Colour of amino acids is based on residue type. D. Structural alignment of SLC22A2 rs316019 protein variants with binding site amino acid residues shown as spheres. Green and purple indicate amino acids of SLC22A2 variants with 270A and 270S, respectively. In C and G, red and green dotted lines denote hydrophobic interactions and hydrogen bonds, respectively.