TABLE III:

QAMat scores for sentences of a relevant and an irrelevant document for an example question

	Question: Orteronel was developed for treatment of which cancer?
Score	Sentence of a relevant document
3.3877	Orteronel also known as TAK-700 is a novel hormonal therapy that is currently in testing for the treatment of prostate cancer.
−0.2706	Orteronel inhibits the 17,20 lyase activity of the enzyme CYP17A1, which is important for androgen synthesis in the testes, adrenal glands and prostate cancer cells.
−2.2917	Preclinical studies demonstrate that orteronel treatment suppresses androgen levels and causes shrinkage of androgen-dependent organs, such as the prostate gland.
0.2731	Early reports of clinical studies demonstrate that orteronel treatment leads to reduced prostate-specific antigen levels, a marker of prostate cancer tumor burden, and more complete suppression of androgen synthesis than conventional androgen deprivation therapies that act in the testes alone.
−2.2761	Treatment with single-agent orteronel has been well tolerated with fatigue as the most common adverse event, while febrile neutropenia was the dose-limiting toxicity in a combination study of orteronel with docetaxel.
−0.3830	Recently, the ELM-PC5 Phase III clinical trial in patients with advanced-stage prostate cancer who had received prior docetaxel was unblinded as the overall survival primary end point was not achieved.
2.2541	However, additional Phase III orteronel trials are ongoing in men with earlier stages of prostate cancer.
Score	Sentence of a random (irrelevant) document
−7.0492	The dynamics of antibody response in guinea pigs infected with Coxiella burnetii was investigated by microagglutination MA and complement-fixation CF tests with different preparations of C. burnetii antigens.
−4.5142	At the onset of antibody response the highest antibody titres were detected by the MA test with natural antigen 2, later on by the MA test with artificial antigen 2.
−7.1499	Throughtout the 1-year period of observation, the CF antibody levels were usually lower and, with the exception of the highest infectious doses, the CF antibodies appeared later than agglutinating antibodies.
−7.1499	There was no difference in the appearance of agglutinating and CF antibodies directed to antigen 1.
−4.2314	Inactivation of the sera caused a marked decrease in antibody titres when tested with artificial antigen 2, whereas the antibody levels remained unchanged when tested with natural antigen 2.