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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2019 Jan 6;1865(3):688–695. doi: 10.1016/j.bbadis.2019.01.009

Figure 1: Effect of niacin on survival following HI.

Figure 1:

(A) Schematic diagram of the experimental design of HI model without fluid resuscitation. (B-E) Niacin prolongs life in rats after HI in the absence of fluid resuscitation. Kaplan-Meier curves (B,D) show survival rate. Groups in panel (B): HI + Veh (n=6), HI + Niacin 1mg/Kg (n=6), HI + Niacin 5 mg/Kg (n=6), HI + Niacin 10mg/Kg (n=6); panel (C): HI + Veh (n=6), NMN 50mg/Kg (n=5) and NMN 10mg/Kg (n=5). (F,G) GPR109a−/− is necessary for niacin-mediated improved survival after HI in the absence of fluid resuscitation. Kaplan-Meier (F) survival curves show survival rate. HI + Veh (WT and GPR109a−/−mice), HI + Niacin 10 mg/Kg (WT and GPR109a−/−mice); n=7. Bars=Mean+SE *indicates p<0.05 compared to HI + Veh. #indicates p<0.05 for HI + Niacin WT compared to HI + Niacin GPR109a−/−.