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| Advantages |
| Comfort of patient |
| Serial monitoring possible |
| Lower sensitivity to tumor heterogeneity (66-68) |
| Reduced time to result (58) |
| Disadvantages |
| No access to histology (SCLC transformation) |
| ctDNA not present in all plasma samples |
ctDNA, circulating tumor DNA; SCLC, small cell lung cancer.
