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. 2019 Jan 24;12:1053. doi: 10.3389/fnins.2018.01053

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Copyright © 2019 Gerace, Landucci, Bani, Moroni, Mannaioni and Pellegrini-Giampietro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electron microscopic evidence for apoptotic cell death in organotypic hippocampal slices. (A,B) Control healthy CA1 pyramidal cells showing healthy mithocondria (black arrow) and synapses rich in vescicles (white arrow) (A) and in longitudinally aligned microtubules in the neuronal processes (black asterisk) (B). (C,D) CA1 pyramidal cells from chronic ethanol slices display suffering mithocondria (black arrow), accumulation of lipofuscins (white arrows) (C) and intercellular empty spaces (black asterisk), but regular synapses (white arrow) and in longitudinally aligned microtubules in the neuronal processes (black arrow) (D). (E,F) Electron microscope morphology in control organotypic slices showing normal synapses with presynaptic vescicles (white arrows) and in longitudinally aligned microtubules in the neuronal processes (black asterisk) (E) and clear signs of apoptosis (black arrows) (F).