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. 2019 Jan 24;7:7. doi: 10.3389/fbioe.2019.00007

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Copyright © 2019 Isupov, Boyko, Sutter, James, Sayer, Schmidt, Schönheit, Nikolaeva, Stekhanova, Mardanov, Ravin, Bezsudnova, Popov and Littlechild.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electron density for the bound substrate AKG in the active site of subunit A of the GEO1900. The 2Fo-Fc electron density map (blue) is contoured at 1.5σ, the positive (green) and negative (red) Fo-Fc electron density maps are contoured at 3.5σ and −3.5σ, respectively. Figure drawn using PyMOL (Schrödinger, LLC).