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. 2019 Jan 24;10:28. doi: 10.3389/fimmu.2019.00028

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Copyright © 2019 Murthy, Singhi, Ross, Loughran, Paragomi, Papachristou, Whitcomb, Zureikat, Lotze, Zeh and Boone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NET inhibition with chloroquine improves survival in murine acute pancreatitis. Chloroquine treatment led to significantly improved survival in murine severe acute pancreatitis (A, median survival unreached vs. 15 days, p = 0.0001, n = 10 per group). These profound findings were confirmed in a second model of murine pancreatitis utilizing administration of choline deficient, ethionine (CDE) supplemented diet (B, median survival unreached vs. 4 days, p = 0.016, n = 20 per group). ^*p < 0.05.