Table 2.

Kinetic evaluation of the interactions between IFNs (R27T and IFN-β-1a) and heterodimeric Fc-fusion receptors (AR1/2Fc).

Ligand	Analyte	k1a × 105	k1d × 10-3	K1D	k2a × 107	k2d × 10-3	K2D
		(M-1s-1)	(s-1)	(nM)	(M-1s-1)	(s-1)	(pM)
AR1/2Fc	R27Ta	1.24	1.231	9.961	14.71	4.535	30.83
	IFN-β-1aa	76.85	0.0044	0.0006	1.57	3.109	198.6

^aSensorgrams fitted using the heterogeneous ligand model (A + B ↔ AB + C ↔ ABC).