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. 2019 Jan 24;9:1547. doi: 10.3389/fphar.2018.01547

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Copyright © 2019 Vasconcelos, Silva, Costa, Oliveira, Souza, Queiroga, Araujo, Cardoso, Righetti, Silva, da Silva, Carvalho, Vieira, Tibério, Cavalcante and Silva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cumulative concentration-response curves to CCh in guinea pig trachea with epithelium in Ctrl (A) and Asth (B), in both the absence and presence of apocynin, tempol or catalase. The symbols and vertical bars represent the mean and SEM, respectively (n = 5). ANOVA one-way followed by Tukey’s post-test: ^∗p < 0.05 [Ctrl E (+) vs. Asth E (+)]. Ctrl: control group; Asth: chronic allergic lung inflammation group; E (+): epithelium present.