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Processing pipeline to classify genes in different categories based on their expression pattern across the cohort. (A) Tests to separate bimodal from non-bimodal genes before subsequent binarization. (B) Test to classify non-bimodal genes in unimodal or zero-inflated genes. (C) Statistical and logical content of the various tests used in (A,B), thresholds have been taken from the papers presenting each tool and are more precisely justified in the Methods section.
