Table 1.
Association of APOL1 G1-G2 variants with HIV-1 acquisition.
| HIV-1 status | n | Age (years)$ | Female& (%) | No. G1-G2 risk alleles | Comparison | Model* | OR (95% CI)* | P* | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | ||||||||
| Seroincident (SI) | 227 | 39.9 ± 6.3 | 25.1 | 88 (38.8%) | 110 (48.5%) | 29 (12.8%) | SI vs. SN | Add | 1.07 (0.84–1.38) | 0.57 |
| Addadj | 1.07 (0.83–1.37) | 0.61 | ||||||||
| Dom | 1.13 (0.80–1.60) | 0.47 | ||||||||
| Domadj | 1.10 (0.78–1.57) | 0.56 | ||||||||
| Rec | 1.02 (0.62–1.70) | 0.98 | ||||||||
| Recadj | 1.04 (0.63–1.74) | 0.87 | ||||||||
| Seroincident (SI) + seroprevalent (SP) | 441 | 40.5 ± 6.2 | 25.0 | 177 (41.8%) | 217 (49.2%) | 47 (10.7%) | SI+SP vs. SN | Add | 0.99 (0.80–1.23) | 0.96 |
| Addadj | 1.00 (0.81–1.24) | 0.99 | ||||||||
| Dom | 1.07 (0.80–1.43) | 0.64 | ||||||||
| Domadj | 1.07 (0.80–1.43) | 0.64 | ||||||||
| Rec | 0.83 (0.54–1.30) | 0.42 | ||||||||
| Recadj | 0.84 (0.54–1.31) | 0.45 | ||||||||
| Seronegative (SN) | 335 | 41.5 ± 7.4 | 29.3 | 140 (41.8%) | 153 (45.7%) | 42 (12.5%) | Reference | - | - | |
There were no associations between APOL1 kidney risk allele status and HIV-1-infection status. $P > 0.05 for SN vs. SI + SP; P < 0.05 for SN vs. SI; & P > 0.05 for SN vs. SI+SP or SN vs. SI.
*
Logistic regression for additive (Add, 2 vs. 1 vs. 0), dominant (Dom, 2 or 1 vs. 0), and recessive (Rec, 2 vs. 1 or 0) genetic models, adjusted (adj) for age (years) and stratified on sex.