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. 2019 Jan 24;10:5. doi: 10.3389/fphys.2019.00005

FIGURE 1.

FIGURE 1

Cryptic protease activity of TTR and cleavage of Apo A-I. (A) HDL complex associated with the antioxidant enzymes. (B) TTR protein bound to thyroxine and retinol-RBP complex. (C) HDL complex with TTR. TTR exhibits no cryptic protease activity until it is bound to retinol-RBP complex. (D) Cryptic protease activity of TTR when retinol-RBP complex is not bound, Apo A-I is cleaved into N and C-terminal. HDL, high density lipoprotein; PON1, paraoxonase; POPC, 1-palmitoyl-2-oleoyl-phosphatidylcholine; RBP, retinol binding protein; TTR, transthyretin.