Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 30;9:948. doi: 10.1038/s41598-018-37442-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

β-catenin and KAP1 share intergenic common DNA binding sites localized mainly on LTRs and ERVs. (a,b) Representative ChIP-qPCR experiment (out of n = 2 independent experiments) of ZFP57 (a) and H3K9me3 (b) recruitment at several ICRs. The data are represented as fold change (2^−ΔΔCt) over IgG (a) or H3 (b) and means ± SD. (c) Venn diagram showing overlapping regions between ChIP-sequencing profiles of β-catenin and KAP1. The peaks between Flag- (β-catenin-Flag) and Biotin- (β-catenin-Biotin) tagged endogenous β-catenin published by Zhang and colleagues⁷³ were intersected among them. The common bound regions were then overlapped with KAP1 ChIP-sequencing peaks performed in BJ1 mESCs by Anvar and colleagues³¹. (d) Bar chart showing genomic distribution of unique and common peaks among β-catenin, KAP1, H3K9me3, H3K4me3. (e) Bar chart showing ChIP-sequencing peaks intersection among KAP1, β-catenin, KAP1, H3K9me3 and Repeat masker. The number of common overlapping peaks is indicated on the top of the bars. (f) Table showing the different LTR and ERV families represented as number (#) and percentage (%) over Repeat maskers (column 2, 3), the total number of common overlapping peaks between β-catenin and KAP1 in BJ1 (column 4, 5), the total number of common overlapping peaks among β-catenin, KAP1 in BJ1 and KAP1 in JB1 mESCs (columns 6, 7).