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. 2019 Jan 30;9:951. doi: 10.1038/s41598-018-37264-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Depletion of USP19 delays tumor growth in vivo. (a) Scheme of xenograft experiments using SKNMC inducible cell lines. (b) Doxycycline-induced shRNA knockdown against USP19 in vivo. Two mice with engrafted tumors of ~200 mm³ (shCtr and shUSP19#1) were treated for five days with doxycycline. Tumor lysates were analyzed by western blotting with anti-USP19. (c) Tumor growth rate of indicated cell lines and treatment of subcutaneously injected SKNMC cells, error bars as SD. (d) Tumors of two representative mice transplanted with SKNMC shUSP19#1 cells and treated with doxycycline or PBS. (e) Immunohistochemical analysis of representative sections doxycycline or PBS treated SKNMC shUSP19#1 tumors using an USP19 antibody.