Table 2.
Variants, tagging regions, significantly associated with the first morbidity hazard (end of healthspan) in 300,447 GCW-British individuals, and results of replication in 96,313 individuals
| SNP | Chr | Position (bp) | EA | RA | EAF | beta | P | β rep | P rep |
|---|---|---|---|---|---|---|---|---|---|
| rs10197246 | 2 | 202,204,741 | C | T | 0.734 | −0.033 | 3.67e-09 | −0.035 | 2.43e-04 |
| rs12203592 | 6 | 396,321 | T | C | 0.214 | 0.063 | 1.80e-25 | 0.043 | 2.10e-05 |
| rs1049053 | 6 | 32,634,405 | T | C | 0.671 | 0.037 | 1.40e-11 | 0.013 | 1.46e-01 |
| rs10455872 | 6 | 161,010,118 | G | A | 0.081 | 0.057 | 4.11e-10 | 0.027 | 1.19e-01 |
| rs140570886 | 6 | 161,013,013 | C | T | 0.016 | 0.116 | 2.18e-08 | 0.131 | 4.09e-04 |
| rs7859727 | 9 | 22,102,165 | T | C | 0.488 | 0.031 | 7.41e-10 | 0.041 | 1.52e-06 |
| rs34872471 | 10 | 114,754,071 | C | T | 0.292 | 0.061 | 9.73e-29 | 0.062 | 2.86e-11 |
| rs2860197 | 10 | 123,351,302 | A | G | 0.613 | −0.029 | 1.22e-08 | −0.007 | 4.47e-01 |
| rs1126809 | 11 | 89,017,961 | A | G | 0.304 | 0.04 | 2.35e-13 | 0.017 | 7.59e-02 |
| rs4784227 | 16 | 52,599,188 | T | C | 0.24 | 0.032 | 3.02e-08 | 0.018 | 7.75e-02 |
| rs4268748 | 16 | 90,026,512 | C | T | 0.311 | 0.038 | 1.55e-12 | 0.004 | 6.24e-01 |
| rs159428 | 20 | 31,099,311 | C | T | 0.527 | 0.028 | 2.36e-08 | −0.005 | 5.84e-01 |
EA, effective (coded, tested) allele; RA, reference (non-coded) allele; EAF, effect allele frequency; β, regression coefficient estimate (units of measurement is log(hazard ratio) per allele); p, p-value after adjustment for genomic control; βrep, regression coefficient estimate in replication sample; prep p-value in replication sample. In bold: replicated loci. In italics: locus demonstrating opposite effect in replication