Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 30;9:987. doi: 10.1038/s41598-018-37699-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Structural characterization of EZH2 SRM-SANT1. (a) The domain architecture of human EZH2. The SRM and SANT1 domain are encased in a dotted black box. The domain architecture of SANT1 and SRM-SANT1 constructs used are shown below. (b) An ¹H-¹⁵N HSQC spectrum of SANT1 (left) and SRM-SANT1 (right). (c) Secondary structure propensity of SRM-SANT1 determined by TALOS+. The predicted secondary structure propensity is shown as a function of residue, ranging between 0 and 1. All predicted secondary structure was alpha helical. * indicates residues with no CO resonance. (d) The TALOS+ determined RCI-S² order parameter is shown as a function of residue number where 0 indicates disordered and 1.0 indicates ordered. * indicates residues with no CO resonance.