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. 2019 Jan 30;9:952. doi: 10.1038/s41598-018-37255-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic diagrams of gene network analyses created in STRING for 3dpf larvae detailing putative protein-protein interactions. Protein functions are colour coded: green – signalling proteins and transcription factors; red – antioxidants and detoxification proteins; purple – transcriptional repressors; blue – varied. (a) Larvae produced from ambient acclimated adults. Gene names: notch1: neurogenic locus notch homolog protein 1; foxl2: Forkhead box L2; hdac5: Histone deacetylase 2; spdef: SAM pointed domain-containing Ets transcription factor; bcor: BCL6 corepressor. (b) Larvae produced from low pH acclimated adults. Gene names, as for (a) plus gpx7, gst01, gsta3, gstt1: members of the Glutathione transferase family; cyp3a4, cyp2, cyp11: members of the CypP450 family; abcc1: Multidrug resistance associated protein 1; crb3: Crumbs protein homolog (involved in morphogenesis); b3gnt1: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (transmembrane protein); bmp2: Bone morphogenetic protein; chrd: Chordin precursor; spen: Msx2-interacting protein; rag1: Recombination activating gene (DNA binding protein); rbm15b: RNA binding protein 15B (RNA binding).