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. 2019 Jan 17;51(1):9. doi: 10.1038/s12276-018-0203-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Chromosomal loci of miR-34 family members. Primary miR-34a (pri-miR-34a; white rectangular boxes) is located on chromosome 1, while pri-miR-34b/c is on chromosome 11. The colored boxes (orange or blue) indicate premature miRNAs. Mature miR-34 sequences are shown in the diagram. Seed sequences are indicated in orange. b Prediction of miR-34 target genes. Target genes of miR-34a and miR-34c were predicted using TargetScan (http://www.targetscan.org). We isolated the negatively correlated genes either with miR-34a or with miR-34c in lung adenocarcinoma data from TCGA (miRGator v3.0, http://mirgator.kobic.re.kr). The combined results are presented in the Venn diagram. c Heatmap of target genes predicted in (b). Genes negatively correlated with miR-34a only, with miR-34c only, or with both miR-34a and miR-34c are presented. The blue color intensity is proportional to the correlation coefficients. d Ingenuity^® Pathway Analysis (molecular and cellular functions) of the miR-34 target genes