Skip to main content
. 2019 Jan 30;9:971. doi: 10.1038/s41598-018-37438-1

Table 1.

Relative expression of Mitochondrial Energy Metabolism genes in aged macrophages at select time points post S. pneumoniae infection (represented in heat map, Fig. 4).

GENE SYMBOL GENBANK Aged, S. pne (30 min) Aged, S. pne (60 min) Aged, S. pne (120 min)
Expression Relative to Aged Control Standard Deviation Expression Relative to Aged Control Standard Deviation Expression Relative to Aged Control Standard Deviation
Ndufab1 NM_028177 1.020 0.445 1.682 0.019 1.356 0.514
Ndufa4 NM_010886 1.580 0.420 3.580 0.241 7.160 0.363
Ndufa6 NM_025987 1.729 0.455 4.317 0.995 9.448 0.289
Ndufa5 NM_026614 1.580 0.521 3.732 0.558 7.464 0.064
Ndufa1 NM_019443 1.729 0.903 4.141 0.378 13.177 0.016
Ndufa7 NM_023202 1.591 0.638 4.028 0.299 9.714 0.069
Ndufa3 NM_025348 1.434 0.049 2.732 0.029 4.756 0.069
Ndufa11 NM_027244 1.376 0.175 2.378 0.013 4.287 0.090
Ndufa2 NM_010885 1.444 0.293 3.249 0.093 5.315 0.146
Ndufa8 NM_026703 1.444 0.781 3.182 0.076 5.618 0.150
Ndufa10 NM_024197 1.087 0.181 1.257 0.081 1.765 0.077
Sdhb NM_023374 1.214 0.473 2.000 0.201 1.591 0.300
Sdhc NM_025321 1.050 0.005 1.248 0.161 1.366 0.505
Sdha NM_023281 0.877 0.122 0.871 0.454 1.149 0.813
Sdhd NM_025848 1.079 0.237 1.094 0.495 1.537 0.385
Uqcrc1 NM_025407 1.035 0.359 1.474 0.038 0.790 0.875
Uqcrc2 NM_025899 1.094 0.394 1.283 0.345 2.603 0.018
Uqcrfs1 NM_025710 1.275 0.006 1.959 0.421 2.395 0.526
Uqcr11 NM_025710 1.537 0.267 2.848 0.301 3.837 0.540
Uqcrh NM_025650 1.670 0.848 3.433 0.760 6.364 0.542
Uqcrq NM_025641 1.659 0.492 4.141 0.857 8.754 0.015
Cyc1 NM_025567 1.310 1.000 1.945 0.146 1.919 0.0741
Bcs1l NM_025784 1.087 0.255 2.129 0.035 2.204 0.745
Cox8a NM_025352 1.050 0.634 1.516 0.291 0.642 0.012
Cox4i2 NM_007750 2.042 0.002 4.056 0.684 5.502 0.012
Cox6a2 NM_053091 0.435 0.503 3.138 0.012 4.595 0.012
Cox4i1 NM_009943 1.329 0.240 2.311 0.199 3.434 0.520
Cox11 NM_009941 1.189 0.329 2.085 0.464 3.531 0.014
Cox6a1 NM_199008 1.591 0.211 3.758 0.118 7.362 0.015
Cox5a NM_007748 1.625 0.582 3.138 0.159 7.516 0.052
Cox6c NM_007747 1.659 0.039 4.563 0.128 10.629 0.852
Cox6b2 NM_053071 1.916 0.190 5.736 0.091 5.205 0.022
Cox5b NM_183405 1.366 0.225 7.516 2.465 2.014 0.022
Cox8c NM_009942 2.462 0.620 25.992 3.471 7.728 0.520
Cox7a2l NM_009187 0.908 0.015 0.908 0.154 0.808 0.0145
Cox6b1 NM_025628 1.919 0.012 5.736 0.867 5.205 0.0152
Cox7b NM_025379 1.892 0.015 4.377 0.965 9.000 1.6845
Cox7a2 NM_009945 4.141 1.025 12.553 1.265 11.794 1.9852
Lhpp NM_029609 0.841 0.540 0.908 0.380 1.505 0.490
Atp5o NM_138597 1.356 1.490 2.219 1.410 3.031 1.250
Ppa2 NM_146141 1.424 1.440 2.219 1.900 3.458 1.090
Atp5g3 NM_175015 1.474 1.630 3.271 1.620 4.757 1.300
Atp5h NM_027862 1.347 1.600 3.074 1.590 4.659 1.480
Atp6v0d2 NM_175406 1.404 0.850 2.173 0.910 4.199 0.900
Atp12a NM_138652 0.986 0.520 3.837 1.480 8.398 1.730
Atp5c1 NM_020615 1.659 0.180 3.706 0.210 8.340 1.890
Atp5j NM_016755 1.892 0.153 4.377 1.970 10.853 1.650
Atp5j2 NM_020582 1.580 1.890 3.630 1.810 7.413 1.650
GENE SYMBOL GENBANK Expression Relative to Aged PRF Control Standard Deviation Expression Relative to Aged PRF Control Standard Deviation Expression Relative to Aged PRF Control Standard Deviation
Ndufab1 NM_028177 1.094 0.0146 1.301 0.8800 1.274 0.0540
Ndufa4 NM_010886 2.462 0.0152 2.828 0.9400 2.204 0.4453
Ndufa6 NM_025987 3.411 0.0215 3.227 0.8200 2.621 0.4500
Ndufa5 NM_026614 2.713 0.0652 2.789 0.7800 2.235 0.7845
Ndufa1 NM_019443 3.095 0.0457 3.117 0.5900 3.272 0.1450
Ndufa7 NM_023202 3.095 0.5412 3.117 0.4900 2.751 0.4530
Ndufa3 NM_025348 2.602 0.6345 2.585 0.2500 2.395 0.4786
Ndufa11 NM_027244 2.235 0.6845 2.099 0.0900 1.972 0.6835
Ndufa2 NM_010885 2.189 0.1460 2.346 0.3000 1.815 0.5431
Ndufa8 NM_026703 2.789 0.0477 2.497 0.4800 2.282 0.4200
Ndufa10 NM_024197 1.404 0.8754 1.189 0.9000 1.189 0.3451
Sdhb NM_023374 2.099 0.5412 2.346 0.7300 1.753 0.3451
Sdhc NM_025321 1.310 0.0254 1.376 0.8900 1.248 0.3785
Sdha NM_023281 0.895 0.0140 1.014 0.6500 1.014 0.7451
Sdhd NM_025848 1.257 0.2560 1.310 0.6500 1.064 0.2100
Uqcrc1 NM_025407 2.378 0.5412 2.462 0.6700 2.189 0.5341
Uqcrc2 NM_025899 1.275 0.6853 1.133 0.3700 1.007 0.0120
Uqcrfs1 NM_025710 1.635 0.0025 1.853 0.4500 1.670 0.0396
Uqcr11 NM_025710 2.378 0.0853 2.462 0.4300 2.189 0.0354
Uqcrh NM_025650 2.445 0.0125 2.346 0.3100 1.840 0.3451
Uqcrq NM_025641 2.949 0.0165 3.294 0.1200 2.585 0.0123
Cyc1 NM_025567 2.028 0.3541 2.250 0.1300 1.602 0.0134
Bcs1l NM_025784 1.558 0.9400 1.932 0.7300 1.505 0.0435
Cox8a NM_025352 1.357 0.0700 1.790 0.6500 1.444 0.1354
Cox4i2 NM_007750 0.864 0.6900 0.757 0.8400 2.479 0.3520
Cox6a2 NM_053091 0.852 0.8000 1.064 0.7200 1.537 0.0320
Cox4i1 NM_009943 2.282 0.6100 2.621 0.3500 2.585 0.3658
Cox11 NM_009941 1.803 0.5400 1.777 0.4400 1.474 0.8300
Cox6a1 NM_199008 2.809 0.4900 3.364 0.2400 3.053 0.2900
Cox5a NM_007748 2.462 0.4400 2.621 0.5000 2.144 0.2700
Cox6c NM_007747 3.031 0.6300 2.949 0.1100 2.462 0.0540
Cox6b2 NM_053071 1.945 0.6000 1.879 0.5700 1.853 0.1570
Cox5b NM_183405 1.101 0.8500 0.758 0.1800 1.485 0.5400
Cox8c NM_009942 2.027 0.5200 4.028 0.8700 3.272 0.7600
Cox7a2l NM_009187 1.301 0.1800 1.366 0.1500 1.257 0.7700
Cox6b1 NM_025628 2.412 0.1500 2.445 0.6700 2.497 0.5100
Cox7b NM_025379 2.828 0.8900 3.010 0.6800 2.395 0.6500
Cox7a2 NM_009945 3.053 0.4500 10.629 0.1500 10.778 0.0093
Lhpp NM_029609 0.785 0.0300 0.598 0.5440 0.697 0.0814
Atp5o NM_138597 2.158 0.5000 2.219 0.5437 1.790 0.0125
Ppa2 NM_146141 2.099 0.7300 2.173 0.0540 1.558 0.0200
Atp5g3 NM_175015 2.362 0.6800 2.532 0.6635 1.853 0.5421
Atp5h NM_027862 2.313 0.5800 2.479 0.3393 2.114 0.9651
Atp6v0d2 NM_175406 1.239 0.7400 1.424 0.5985 1.238 0.6523
Atp12a NM_138652 2.204 0.3000 2.313 0.6531 2.462 0.6130
Atp5c1 NM_020615 3.160 0.0400 3.458 0.9631 2.694 0.4610
Atp5j NM_016755 3.117 0.2900 3.095 0.3268 2.362 0.4130
Atp5j2 NM_020582 2.732 0.7500 2.828 0.0635 2.346 0.2541