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. 2019 Jan 30;9:1005. doi: 10.1038/s41598-018-37835-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Occurrence of the 2-hit combinations identified in tumor samples, for three representative cancer types. Figure S3 shows the distribution for all seventeen cancer types. The top combination occurs in 65% of tumor samples, on average, while 42% of the combinations occur in less than 5% of the samples. Total percentage exceeds 100% because samples can contain multiple combinations.