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. 2019 Jan 30;9:1005. doi: 10.1038/s41598-018-37835-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Weight computation for a combination of two genes 〈gene1, gene2〉. Tumor samples covered by both genes are true positives (TP), tumor samples not covered by one or both genes are false negatives (FN), normal samples covered by both genes are false positives (FP), and normal samples not covered by one or both genes are true negatives (TN). The scaling factor α is used to balance the relative importance of sensitivity and specificity.