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. 2019 Jan 30;9:973. doi: 10.1038/s41598-018-37801-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A disease pedigree constructed around the affected dogs. The ALPL genotypes are denoted with different colours. Several inbreeding loops and common ancestors are present. Within the affected litters, samples were obtained from altogether three parents and twelve unaffected full siblings. In both litters 1 and 2, one puppy had died without sampling or clinical and pathological examinations, at the age of 3 weeks (litter 1) and 2 days (litter 2). The genotype and possible affection status of these puppies could not therefore be determined.