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. 2019 Jan 30;9:977. doi: 10.1038/s41598-018-37403-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lipid distribution in adipose tissue and liver is altered in BAFF^−/− mice fed an HFD. (A) Changes in body weight of BAFF^−/− and WT mice fed an ND or HFD (n = 25–55/group). (B) Organ weight [(organ weight/body weight) × 100%] in BAFF^−/− and WT mice fed an ND (n = 6/group) or HFD (n = 7/group) for 24 weeks. For all bar plots shown, data are expressed as the mean ± SD, and significance was determined by two-tailed Student’s t test (A) and Mann–Whitney U test (B). ^♯♯♯P < 0.001 compared to WT-ND mice. *P < 0.05, **P < 0.01, and ***P < 0.001 compared to WT-HFD mice. BAFF, B cell-activating factor; WT, wild-type; ND, normal diet; HFD, high-fat diet; SAT, subcutaneous adipose tissue; EAT, epididymal adipose tissue; RpAT, retroperitoneal adipose tissue; VAT, visceral adipose tissue; BAT, brown adipose tissue.