Figure 2.

BAFF^−/− mice are protected against glucose intolerance and insulin resistance. (A) Fasting blood glucose, plasma insulin, and HOMA-IR values in HFD-fed BAFF^−/− and WT mice over the course of 12 weeks (n = 6/group). (B) Glucose- and (C) insulin-tolerance tests (left) and corresponding area under the curve (AUC) values during the tests (right) (n = 7–14/group). For all bar plots, data are expressed as the mean ± SD, and significance was determined by the Mann–Whitney U test. *P < 0.05, **P < 0.01, and ***P < 0.001. BAFF, B cell-activating factor; WT, wild-type; ND, normal diet; HFD, high-fat diet; HOMA-IR, calculated homeostasis model assessment of insulin resistance.