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. 2019 Jan 30;9:977. doi: 10.1038/s41598-018-37403-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The expression of genes related to steatosis is downregulated in the livers of BAFF^−/− mice. (A,C,D) The expression of genes related to lipogenesis (A), inflammation (C), and fibrosis (D) in mouse livers after 24 weeks of HFD consumption (n = 9–14/group). (B) The expression of proteins related to lipogenesis (n = 4/group). Original gel documents of western blot were shown in Supplementary Fig. S4. Protein levels were normalized to those of β-actin, and those of WT mice were set at 1. For all bar plots, data are expressed as the mean ± SEM, and significance was determined by Mann–Whitney U test. *P < 0.05 and ***P < 0.001. BAFF, B cell-activating factor; WT, wild-type; HFD, high-fat diet; FAS, fatty acid synthase; SREBP1, sterol regulatory element-binding protein; ACC, acetyl-CoA carboxylase; SCD, stearoyl-CoA desaturase; ACS, acetyl-CoA synthetase; MTP, microsomal triglyceride transfer protein; TNF, tumour necrosis factor.