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. 2019 Jan 30;9:966. doi: 10.1038/s41598-018-37413-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Weighted gene coexpression network analysis (WGCNA) identified modules of co-expressed genes. Values of Zsummary above 10 represent modules of genes highly preserved. Values between 2 and 10 represent poor to moderate preservation, which can indicate sets of genes influenced by melatonin treatment. (A) Three modules of genes with moderated preservation (pink, magenta and black) were identified to MDA-MB-231 human breast cancer cells; (B) Three modules of genes with moderated preservation (darkolivegreen, yellowgreen and orangered) were identified to the tumor microenvironment (murine cells).