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. 2019 Jan 30;10:487. doi: 10.1038/s41467-019-08417-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — TF mobility correlates with the mitotic bound fraction and interphase ψon-rate. a, b Top: Example of FRAP for CDX2-YPet (a) and HOXD10-YPet (b) for cells in interphase and mitosis (scale bar: 5 µm). Bottom: normalized interphase and mitosis FRAP recovery curves for CDX2-YPet (a) and HOXD10-YPet (b). c Correlation between FRAP t_1/2 recovery of TFs in interphase and mitosis. d Correlation between TF mitotic bound fraction and FRAP t_1/2 recovery in interphase. e Correlation between TF mitotic bound fraction and FRAP t_1/2 recovery in mitosis. f Correlation between TF mitotic bound fraction and FRAP immobile fraction in interphase. g Correlation between TF mitotic bound fraction and FRAP immobile fraction in mitosis. h Correlation between FRAP t_1/2 recovery in interphase and the ψon-rate. i Correlation between FRAP t_1/2 recovery in mitosis and the ψon-rate. j Correlation between FRAP t_1/2 recovery in interphase and TF relative residence times. k Correlation between FRAP t_1/2 recovery in mitosis and TF relative residence times. Error bars: SEM. r-values (r) and p-values (p) are based on Pearson correlation. For FRAP relative intensity, t_1/2 recovery time and immobile fraction: n = 10