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. 2019 Jan 30;9:993. doi: 10.1038/s41598-018-38177-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Box plots of the chemomarkers annotated in Lobophora species responsible for metabolomic differences according to sites. Ion intensities of chemomarkers are expressed as mean normalized intensities ± SD (log-transformed data). For (a) Lobophora rosacea: n = 6 for Banc Nord (BN), Canard (Can) and Ricaudy (Ric), n = 5 for Larégnère (Lar) and n = 4 for Crouy (Cro). Statistical analyses were performed using Kruskal-Wallis (KW) followed by post-hoc Conover’s test. Letters represent distinct groups based on post-hoc pairwise comparisons between sites for each chemomarker (p < 0.05). Compounds M230T256, M242T309, M258T310 and M344T346 are shown in Fig. S4 and present the same trend as M332T377. For (b) Lobophora sonderii and (c) Lobophora obscura: n = 6 and differences between ion intensities at Crouy vs Ricaudy were tested with Mann-Whitney tests (*p < 0.01). Compounds M258T310 and M368T338 of Lobophora sonderii are shown in Fig. S4 and present the same trend as M370T362.