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. 2019 Jan 30;9:950. doi: 10.1038/s41598-018-37521-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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p73 and AP2 affect NEU4 expression. (A) sialyl Lewis X was down-regulated under starvation conditions in HT29 cells (orange line, isotype control under full serum culture; blue line, isotype control under starvation; green line, sialyl Lewis X under full serum culture; red line, sialyl Lewis X under starvation). (B) Sialyl Lewis A levels did not change under starvation conditions in HT29 cells (orange line, isotype control under full serum culture; blue line, isotype control under starvation; green line, sialyl Lewis A under full serum culture; red line, sialyl Lewis A under starvation). (C) NEU4, but not FUT2, mRNA was increased by p73 overexpression in HT29 cells. (D,E,F) Knock-down of p73 (D) or AP2α (E) in HT29 cells or of AP2γ in DLD1 cells (F) reduced NEU4 mRNA. (C–F) Results are displayed as mean ± SD, n = 3 (***p < 0.001, **p < 0.01, *p < 0.05).