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. 2019 Jan 30;9:950. doi: 10.1038/s41598-018-37521-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The NEU4 promoter is activated by p73 and AP2γ in HT29 cells. (A) Promoter sequence of NEU4 V34. P1–P3 are the potential binding sites for the p53 family members predicted by JASPAR software. The boldface letters represent the AP2 potential binding site predicted by JASPAR software. (B) Over-expression of p73 activated the NEU4 promoter, and mutation of P3 reduced the activation function of p73. (C) Over-expression of AP2γ activated the NEU4 promoter, and mutation of the AP2 potential binding site, but not mutation of P1, reduced the activation function of AP2γ. (D) Starvation conditions activated the NEU4 promoter, and this effect was partially reduced when the promoter contained P3 and AP2 mutations. (B–D) Results are displayed as mean ± SD, n = 3 (***p < 0.001, **p < 0.01, *p < 0.05).