Table 2.
Laboratory parameters, ELISA and LC–MS measurements
| Parameter | Baseline | Pre | Onset | 24 h | 48 h | 7d | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Healthy | Surgical | Surgical | Sepsis | Surgical | Sepsis | Surgical | Sepsis | Surgical | Sepsis | |
| Leucocytes (1/nL) | 6.16 (5.11–7.58) | 6.14 (4.53–8.42) | 12.18 (9.71–14.89) | 19.21 (7.74–27.31) | 11.71 (8.96–13.95) | 19.86 (12.51–33.36) | 9.51 (7.64–12.00) | 19.95 (12.31–30.84) | 10.35 (7.65–13.30) | 14.21 (9.52–20.05) |
| 0.039* | < 0.001*** | < 0.001*** | 0.115 | |||||||
| CRP (mg/L) | 2.00 (2.00–2.85) | 2.00 (2.00–6.65) | 2.70 (2.00–9.85) | 218.90 (144.05–269.08) | 133.70 (90.63–157.40) | 263.25 (159.75–320.30) | 143.30 (112.10–162.30) | 179.00 (116.25–293.05) | 68.30 (29.45–130.70) | 120.90 (72.30–158.10) |
| < 0.001*** | < 0.001*** | 0.041* | 0.150 | |||||||
| PCT (ng/mL) | 0.05 (0.05–0.05) | 0.05 (0.05–0.07) | 0.09 (0.05–0.19) | 17.54 (1.68–48.18) | 1.08 (0.43–2.18) | 11.96 (3.27–35.07) | 0.78 (0.36–1.49) | 8.99 (1.77–28.69) | 0.11 (0.10–0.81) | 1.03 (0.47–1.45) |
| < 0.001*** | < 0.001*** | < 0.001*** | 0.008** | |||||||
| TAT (ng/mL) | 3.30 (2.40–6.60) | 9.90 (6.33–11.35) | 9.90 (6.68–11.70) | 12.85 (11.16–14.83) | 9.23 (5.91–13.38) | 12.53 (10.84–15.28) | 10.30 (5.35–12.95) | 13.73 (11.28–17.48) | 10.90 (6.83–13.40) | 14.70 (11.63–18.45) |
| < 0.001*** | 0.003** | 0.001** | 0.021* | |||||||
| D-dimer (mg/L) | 0.37 (0.26–0.57) | 0.48 (0.34–0.85) | 3.55 (1.85–4.13) | 7.59 (4.54–13.85) | 3.50 (2.23–4.10) | 6.94 (4.16–12.27) | 2.41 (1.85–3.38) | 6.77 (4.14–11.87) | 4.68 (3.78–5.84) | 5.47 (4.32–7.43) |
| < 0.001*** | 0.001** | < 0.001*** | 0.412 | |||||||
| PT index (%) | 109.5 (104.70–117.30) | 94.00 (88.30–100) | 91.00 (78.20–98.75) | 68.75 (46.85–76.35) | 70.05 (61.30–84.40) | 65.80 (53.63–85.65) | 94.00 (85.70–100.90) | 81.00 (65.75–92.13) | 96.80 (89.85–113.80) | 81.90 (71.40–91.60) |
| < 0.001*** | 0.304 | 0.008** | 0.004** | |||||||
| aPTT (s) | 24.00 (22.65–25.90) | 23.80 (22.65–25.90) | 22.00 (20.60–23.95) | 32.90 (28.45–37.80) | 26.35 (24.53–28.48) | 37.80 (31.33–44.53) | 26.30 (23.80–28.00) | 33.90 (27.65–40.55) | 24.50 (21.50–27.05) | 27.90 (26.10–35.00) |
| < 0.001*** | < 0.001*** | < 0.001*** | 0.009** | |||||||
| Platelet count (1/nL) | 249.00 (209.50–275.75) | 183.00 (167.50–232.50) | 200.00 (172.00–248.50) | 181.50 (101.50–229.50) | 156.00 (133.00–191.80) | 152.5 (59.30–253.00) | 156.00 (137.00–197.00) | 142.00 (68.00–255.00) | 264.00 (246.00–315.50) | 258.00 (204.50–377.50) |
| 0.157 | 0.408 | 0.252 | 0.755 | |||||||
| PG F1α (pg/mL) | 22.9 (20.7–48.0) | 82.0 (45.8–121.4) | 54.9 (28.3–71.2) | 278.3 (50.3–591.3) | 10.1 (5.2–45.5) | 431.0 (117.9–972.2) | 7.7 (2.0–27.9) | 283.9 (97.7–1165.8) | 7.5 (1.2–59.1) | 345.2 (48.4–689.0) |
| < 0.001*** | < 0.001*** | < 0.001*** | 0.016* | |||||||
| 11d-TX B2 (pg/mL) | 45.6 (36.9–73.4) | 8.3 (5.1–19.8) | 9.5 (5.6–14.6) | 18.7 (9.6–39.7) | 12.6 (7.7–34.2) | 48.7 (21.9–159.4) | 20.6 (11.8–48.2) | 54.4 (28.6–144.0) | 13.5 (8.6–41.0) | 18.3 (7.9–45.1) |
| 0.013* | < 0.001*** | 0.005** | 0.893 | |||||||
Data are presented by median and interquartile range (Q1–Q3)
TAT thrombin–antithrombin complex, INR international normalized ratio, aPTT activated partial thromboplastin time, CRP C-reactive protein, PCT procalcitonin, PT index prothrombin index, PG F1α prostaglandin F1α, 11d-TX B2 11-dehydro Thromboxane B2
A P value < 0.05 was considered statistically significant. Concerning symbolism and higher orders of significance: *P < 0.05, **P < 0.01, ***P < 0.001