Table 3.
Viscoelastic and aggregometric POCT
| Timepoints | Baseline | Pre | Onset | 3 h | 6 h | 12 h | 24 h | 48 h | 7d | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Groups | Healthy | Surgical | Surgical | Sepsis | Surgical | Sepsis | Surgical | Sepsis | Surgical | Sepsis | Surgical | Sepsis | Surgical | Sepsis | Surgical | Sepsis |
| Viscoelastic POCT (EXTEM test) | ||||||||||||||||
| CT (s) (normal range 38–79 s) | 57.0 (54.0–60.0) | 60.0 (55.5–67.0) | 60.0 (55.0–70.0) | 81.5 (67.8–91.8) | 60.0 (54.5–65.5) | 78.0 (70.8–89.8) | 59.0 (53.0–66.0) | 82.0 (67.0–88.0) | 66.5 (61.3–71.0) | 82.0 (74.0–90.0) | 59.0 (55.0–64.0) | 81.0 (69.0–86.0) | 62.0 (57.0–69.0) | 72.0 (66.8–78.0) | 71.0 (64.0–78.0) | 76.0 (66.0–82.5) |
| < 0.001*** | < 0.001*** | < 0.001*** | < 0.001*** | < 0.001*** | 0.001** | 0.358 | ||||||||||
| LI 45 min (%) (normal range > 85%) | 96.0 (94.0–98.0) | 97.0 (96.0–98.5) | 98.0 (96.0–98.5) | 99.0 (98.0–100.0) | 97.0 (96.0–99.0) | 99.0 (98.0–100.0) | 97.0 (96.0–99.0) | 99.0 (98.0–100.0) | 96.0 (95.0–98.0) | 99.0 (98.0–100.0) | 95.0 (92.0–97.0) | 100.0 (98.0–100.0) | 95.0 (93.0–97.0) | 100.0 (98.0–100.0) | 97.0 (94.5–98.0) | 99.0 (98.5–100.0) |
| 0.032* | 0.004** | 0.008** | < 0.001*** | < 0.001*** | < 0.001*** | 0.002** | ||||||||||
| LI 60 min (%) (normal range > 85%) | 92.0 (90.0–93.75) | 93.0 (92.0–95.0) | 96.0 (94.5–96.0) | 97.0 (96.0–99.0) | 95.0 (93.0–97.0) | 97.0 (95.3–99.0) | 94.0 (92.0–96.0) | 98.0 (96.0–99.0) | 93.0 (91.0–94.0) | 97.0 (95.0–99.0) | 88.0 (86.0–92.0) | 98.0 (95.0–99.0) | 90.5 (87.0–93.75) | 98.5 (96.0– 100.0) | 92.0 (90.0–95.0) | 97.5 (96.3–98.8) |
| 0.027* | 0.032* | 0.079 | < 0.001*** | < 0.001*** | < 0.001*** | 0.005** | ||||||||||
| Aggregometric POCT | ||||||||||||||||
| ADP test AUC (U*min) (normal range 53–122) | 65.0 (52.8–82.8) | 63.5 (42.3–83.8) | 83.5 (47.0–100.5) | 29.0 (19.8–58.8) | 58.0 (25.5–92.0) | 36.0 (19.0–55.5) | 52.0 (37.0–108.0) | 34.5 (15.8–60.8) | 73.0 (37.0–197.5) | 48.0 (18.0–70.0) | 58.5 (39.8–80.5) | 40.0 (17.0–61.0) | 53.0 (34.5–69.5) | 27.0 (13.3–44.8) | 104.0 (80.0–139.5) | 71.0 (31.0–108.0) |
| < 0.001*** | 0.143 | 0.009** | 0.101 | 0.022* | 0.008** | 0.059 | ||||||||||
| ASPI test AUC (U*min) (normal range 75–136) | 107.0 (94.8–117.8) | 93.5 (77.3–112.8) | 78.5 (45.5–104.3) | 64.5 (24.3–92.0) | 41.0 (28.5–88.5) | 57.0 (22.0–105.0) | 45.0 (27.0–89.0) | 53.0 (27.8–100.8) | 55.0 (27.0–75.5) | 52.0 (24.0–107.0) | 48.5 (19.8–74.3) | 58.0(26.0–104.0) | 37.5(23.5–58.0) | 49.0 (23.8–111.8) | 118.0 (66.5–146.5) | 102.0 (75.5–143.5) |
| 0.451 | 0.564 | 0.583 | 0.444 | 0.91 | 0.191 | 0.729 | ||||||||||
| COL test AUC (U*min) (normal range 46–117) | 87.0 (72.0–106.8) | 63.5 (49.3–80.3) | 63.0 (42.0–98.0) | 43.0 (33.3–66.5) | 53.0 (32.0–100.0) | 58.0 (26.5–116.0) | 86.0 (49.0–116.0) | 55.5 (22.3–87.0) | 94.0 (37.5–119.0) | 77.0 (29.0–95.0) | 58.5 (29.8–92.0) | 56.0 (35.0–88.0) | 52.0 (26.5–69.5) | 54.0 (29.3–96.0) | 91.0 (64.0–110.0) | 59.0 (42.5–120.5) |
| 0.680 | 0.932 | 0.062 | 0.277 | 1.00 | 0.406 | 0.405 | ||||||||||
| ADP test AUC (U*min) (normal range 53–122) | 65.0 (52.8–82.8) | 63.5 (42.3–83.8) | 83.5 (47.0–100.5) | 29.0 (19.8–58.8) | 58.0 (25.5–92.0) | 36.0 (19.0–55.5) | 52.0 (37.0–108.0) | 34.5 (15.8–60.8) | 73.0 (37.0–197.5) | 48.0 (18.0–70.0) | 58.5 (39.8–80.5) | 40.0 (17.0–61.0) | 53.0 (34.5–69.5) | 27.0 (13.3–44.8) | 104.0 (80.0–139.5) | 71.0 (31.0–108.0) |
| < 0.001*** | 0.143 | 0.009** | 0.101 | 0.022* | 0.008** | 0.059 | ||||||||||
Data are presented by median and interquartile range (Q1–Q3)
CT clotting time, LI lysis index, AUC area under the curve
A P value < 0.05 was considered statistically significant. Concerning symbolism and higher orders of significance: *P < 0.05, **P < 0.01, ***P < 0.001