Central Illustration.

Major Adverse Cardiac Events in Left Anterior Descending–Deferred Patients: Kaplan-Meier Curves

This figure outlines the primary endpoint in patients with left anterior descending stenoses who were deferred according intracoronary physiology. Major adverse cardiac events were defined as the composite of cardiovascular death, myocardial infarction, and unplanned revascularization. The solid blue line denotes the fractional flow reserve arm, and the dashed orange line denotes the instantaneous wave-free ratio arm. Instantaneous wave-free ratio–guided deferral was associated with a significantly lower major adverse cardiac events rate (adjusted hazard ratio: 0.46; 95% confidence interval: 0.22 to 0.95; p = 0.04).