Table 1.
The alteration frequency of CTNNB1 in endometrial, liver, and colorectal cancer
| Cancer type | Sequencing data source | No. Sequenced | No. Alteration (%) | No. Exon3-mut (%) | Reference |
|---|---|---|---|---|---|
| Endometrial cancer | Endometrial Cancer (MSK, 2018) | 187 | 27 (14.4) | 25 (13.4) | Soumerai et al., 2018 |
| Uterine Corpus Endometrial Carcinoma (TCGA, Nature 2013) | 240 | 71 (29.6) | 63 (26.3) | Cancer Genome Atlas Research et al., 2013a | |
| Uterine Carcinosarcoma (TCGA, PanCancer Atlas) | 56 | 1 (1.8) | 0 (0.0) | Cancer Genome Atlas Research et al., 2013b | |
| Uterine Clear Cell Carcinoma (NIH, Cancer 2017) | 16 | 0 (0.0) | 0 (0.0) | Le Gallo et al., 2017 | |
| Liver cancer | Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) | 353 | 95 (26.9) | 78 (22.1) | Cancer Genome Atlas Research et al., 2013b |
| Liver Hepatocellular Carcinoma (AMC, Hepatology 2014) | 231 | 53 (22.9) | 46 (19.9) | Ahn et al., 2014 | |
| Liver Hepatocellular Carcinoma (RIKEN, Nat Genet 2012) | 25 | 3 (12.0) | 3 (12.0) | Fujimoto et al., 2012 | |
| Hepatocellular Carcinomas (Inserm, Nat Genet 2015) | 243 | 87 (35.8) | 76 (31.3) | Schulze et al., 2015 | |
| Hepatocellular Adenoma (Inserm, Cancer Cell 2014) | 30 | 13 (43.3) | 11 (36.7) | Pilati et al., 2014 | |
| Colorectal cancer | Colorectal Adenocarcinoma (TCGA, Nature 2012) | 212 | 11 (5.2) | 1 (0.5) | Cancer Genome Atlas, N. et al., 2012 |
| Colorectal Adenocarcinoma (Genentech, Nature 2012) | 72 | 5 (6.9) | 2 (2.8) | Seshagiri et al., 2012 | |
| Colorectal Adenocarcinoma (DFCI, Cell Reports 2016) | 619 | 31 (5.0) | 8 (1.3) | Giannakis et al., 2016 | |
| Metastatic colorectal cancer (MSK, Cancer Cell 2018) | 1099 | 84 (7.6) | 19 (1.7) | Yaeger et al., 2018 | |
| Colon Adenocarcinoma (TCGA, PanCancer Atlas) | 389 | 27 (6.9) | 15 (3.9) | Cancer Genome Atlas Research et al., 2013b | |
| Rectum Adenocarcinoma (TCGA, PanCancer Atlas) | 137 | 8 (5.8) | 0 (0.0) | Cancer Genome Atlas Research et al., 2013b |
*
Data obtained from the listed cancer studies on cBioportal (www.cbioportal.org)