Table 2.
Status of mutations in cancer cell lines harboring activating mutations of CTNNB1
| Cancer type | Cell Line | Mutations | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| CTNNB1 | APC | TP53 | BRAF | KRAS | ||
| Colorectal cancer | SW48 | S33Y | R2714C | |||
| CCK81 | T41A | Y159C | P278H | S273N | ||
| SNU407 | T41A | R726C | G12D | |||
| HCT116 | S45del | G13D | ||||
| LS180 | S45F | R1788C | D211G | G12D | ||
| Gastric cancer | KE39 | D32N | V272L | |||
| AGS | G34E | G12D | ||||
| SNU719 | G34V | |||||
| OCUM1 | S45C | |||||
| Endometrial cancer | HEC265 | D32V, X561_splice | P1233L | |||
| HEC6 | D32V | V160A | ||||
| HEC108 | S37P, D207G | S678G, A2388V, T2514I | P151H | |||
| JHUEM2 | S37C | |||||
| SNGM | S37P | A2V | G12V | |||
| Lung cancer | MORCPR | S33L | P865L, A2122dup | P152Rfs*18 | G13C | |
| SW1573 | S33F | G12C | ||||
| LXF289 | T41A | R248W | ||||
| HCC15 | S45F, Y670* | D2796G | D259V | |||
| Liver cancer | HUH6 | G34V | N239D, A159D | |||
| SNU398 | S37C | |||||
| Melanoma | SKMEL1 | S33C | V600E | |||
| COLO783 | S45del | P27L | V600E | |||
*
Mutation data obtained from Cancer Cell Line Encyclopedia (Novartis/Broad, Nature, 2012) on cBioportal (www.cbioportal.org).
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Abbreviation: del, deletion; dup, duplication; fs, frame shift; splice, splice site mutation;
*
stop codon