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. 2019 Jan 2;42(1):1–7. doi: 10.14348/molcells.2018.0419

Fig. 1. Structures of TAM family receptors and their ligands.

Fig. 1

Ig superfamily domains of each TAM receptor recognize their ligands. The extracellular domain of each TAM family receptor contains two Ig superfamily domains and two fibronectin type III domains. The cytoplasmic tail of each TAM family receptor contains well conserved “KW(I/L)A(I/L)ES” signature sequence. Also, the cytoplasmic tail of each TAM family receptor contains a conserved protein tyrosine kinase (PTK) domain and immunoreceptor tyrosine based inhibitory motif (ITIM) domain. Autophosphorylation sites of each TAM family receptor are located within PTK domain. Both Gas6 and Pros1 have γ-carboxyglutamate-rich domain (Gla domain) at their amino terminus. Also, both proteins contain four epidermal growth factor (EGF)-like domains and one sex hormone binding globulin (SHBG) domain which consists of two globular laminin G-like (LG) domain. Gas6 can bind to all three TAM family receptors with the highest affinity to Axl, whereas Pros1 can interact with Mer or Tyro3, but not Axl.