Comparison 4. Group 2 Pulmonary hypertension due to left heart disease (sildenafil v placebo).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Improvement in WHO functional class	3	285	Odds Ratio (M‐H, Fixed, 95% CI)	0.53 [0.32, 0.87]
2 Six‐minute walk distance	3	284	Mean Difference (Fixed, 95% CI)	34.31 [22.75, 45.87]
3 Mortality	3	286	Odds Ratio (M‐H, Fixed, 95% CI)	1.27 [0.28, 5.80]
4 mean PAP	3	130	Mean Difference (Fixed, 95% CI)	‐10.17 [‐11.99, ‐8.35]
5 Cardiac Index	2	96	Mean Difference (Fixed, 95% CI)	0.07 [‐0.17, 0.30]
6 TPG	1		Mean Difference (Fixed, 95% CI)	Totals not selected
7 RAP	1		Mean Difference (Fixed, 95% CI)	Totals not selected
8 PASP	1		Mean Difference (Fixed, 95% CI)	Totals not selected
9 Dyspnoea	1		Mean Difference (Fixed, 95% CI)	Totals not selected
10 Clinical worsening	2	234	Odds Ratio (M‐H, Random, 95% CI)	0.87 [0.22, 3.46]