Comparison 6. Group 4 Pulmonary Hypertension due to CTEPH.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Improvement in WHO functional class	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
2 Six‐minute walk distance	3		Mean Difference (Fixed, 95% CI)	Subtotals only
2.1 Sildenafil versus placebo	1	19	Mean Difference (Fixed, 95% CI)	17.5 [‐23.90, 58.90]
2.2 Sildenafil versus bosentan	2	227	Mean Difference (Fixed, 95% CI)	20.42 [‐27.95, 68.79]
3 Mortality	2		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Sildenafil versus placebo	1	20	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.2 Sildenafil versus bosentan	1	106	Odds Ratio (M‐H, Fixed, 95% CI)	1.36 [0.22, 8.48]
4 mean PAP	3		Mean Difference (Fixed, 95% CI)	Subtotals only
4.1 Sildenafil versus placebo	1	19	Mean Difference (Fixed, 95% CI)	‐6.2 [‐12.40, ‐0.00]
4.2 Sildenafil versus bosentan	2	227	Mean Difference (Fixed, 95% CI)	0.76 [‐3.96, 5.48]
5 Cardiac Index	3		Mean Difference (Fixed, 95% CI)	Subtotals only
5.1 Sildenafil versus placebo	1	19	Mean Difference (Fixed, 95% CI)	0.0 [‐0.40, 0.40]
5.2 Sildenafil versus bosentan	2	227	Mean Difference (Fixed, 95% CI)	0.04 [‐0.22, 0.31]
6 PVR	3		Mean Difference (Fixed, 95% CI)	Subtotals only
6.1 Sildenafil versus placebo	1	19	Mean Difference (Fixed, 95% CI)	‐0.89 [‐1.85, 0.06]
6.2 Sildenafil versus bosentan	2	227	Mean Difference (Fixed, 95% CI)	‐0.01 [‐0.27, 0.25]
7 RAP	2		Mean Difference (Fixed, 95% CI)	Subtotals only
7.1 Sildenafil versus placebo	1	19	Mean Difference (Fixed, 95% CI)	‐0.9 [‐6.10, 4.30]
7.2 Sildenafil versus bosentan	1	121	Mean Difference (Fixed, 95% CI)	‐1.0 [‐3.77, 1.77]
8 QOL	1		Mean Difference (Fixed, 95% CI)	Totals not selected
9 Adverse events	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
9.1 Headache	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
9.2 GI upset	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]