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. 2019 Jan 24;13:1. doi: 10.3389/fnsys.2019.00001

Figure 2.

Figure 2

Miniature PSCs (mPSCs) are down regulated by s-GO in organotypic ventral horns. Sample tracings are mPSCs recorded in Control and s-GO (50 μg/mL) treated cultures (top left panel). Top right: plot reporting mPSCs frequency values in control and in the three different s-GO concentrations tested. Note that s-GO treatments (25 and 50 μg/mL) significantly decreased the frequency of mPSCs (*P < 0.05 and **P < 0.01). Bottom: column plots summarize the average values of AMPA-glutamate (left; mEPSCs) and GABAA (right, mIPSCs) receptor mediated miniature events, pharmacologically isolated. In s-GO treatments (50 μg/mL) a significant decrease in the frequency of both types of miniature was detected (*P < 0.05 and **P < 0.01, respectively).