Table 1.
Sirtuins localization and function
| Sirtuin | Localization | Enzymatic activity | General functions | References |
| SIRT1 | Nucleus Cytoplasm | Deacetylase Deacylase | Metabolism Mitochondrial biogenesis Cellular stress Chromatin regulation Cell differentiation | [30] |
| SIRT2 | Cytoplasm Nucleus | Deacetylase Demyristoylase ADP-ribosylase Deacylase | Cell cycle Cell differentiation Metabolism Tumor suppression | [97] |
| SIRT3 | Mitochondria | Deacetylase Decrotonylase Deacylase | Metabolism Mitochondrial biogenesis Antioxidant activity | [98,99] |
| SIRT4 | Mitochondria | ADP-ribosylase Lipoamidase Deacetylase Deacylase | Tumor suppression Metabolism Tumor suppression | [100] |
| SIRT5 | Mitochondria | Desuccinylase Deacylase Demalonylase Deglutarylase Deacetylase | Metabolism | [101] |
| SIRT6 | Nucleus | Deacylase Deacetylase ADP-ribosylase | DNA repair Metabolism Inflammation | [102] |
| SIRT7 | Nucleus | Deacetylase Deacylase | Ribosome biogenesis Tumor promotion Metabolism | [103] |
ADP: Adenine diphosphate; SIRT: Sirtuin.