TABLE 2.
Biodistribution of 177Lu-PSMA-I&F and 68Ga-PSMA-I&F in CB17 SCID and LNCaP Xenograft–Bearing SHO Mice, Respectively (n = 4–5)
|
177Lu-PSMA-I&F |
||||
| Organ | 1 h after injection | 6 h after injection | 68Ga-PSMA-I&F, 1 h after injection | 68Ga-PSMA-I&T, 1 h after injection |
| Blood | 1.4 ± 0.2 | 0.29 ± 0.03 | 2.1 ± 0.4 | 0.5 ± 0.2 |
| Heart | 0.8 ± 0.1 | 0.24 ± 0.04 | 1.0 ± 0.1 | 0.3 ± 0.1 |
| Lung | 2.0 ± 0.3 | 0.81 ± 0.18 | 2.1 ± 0.5 | 1.5 ± 0.4 |
| Liver | 1.4 ± 0.5 | 0.58 ± 0.08 | 0.9 ± 0.1 | 1.0 ± 0.4 |
| Spleen | 14.6 ± 3.9 | 5.71 ± 0.60 | 12.8 ± 6.5 | 3.9 ± 1.5 |
| Pancreas | 0.8 ± 0.2 | 0.23 ± 0.04 | 0.7 ± 0.1 | 0.5 ± 0.2 |
| Stomach | 0.6 ± 0.1 | 0.28 ± 0.06 | 0.7 ± 0.1 | 0.4 ± 0.1 |
| Intestines | 0.4 ± 0.1 | 0.29 ± 0.10 | 0.5 ± 0.2 | 0.3 ± 0.1 |
| Kidneys | 76.9 ± 4.2 | 72.62 ± 5.88 | 105.8 ± 22.7 | 53.3 ± 9.0 |
| Muscle | 0.4 ± 0.1 | 0.11 ± 0.03 | 0.5 ± 0.1 | 0.4 ± 0.1 |
| LNCaP tumor | — | — | 4.5 ± 1.8 | 4.9 ± 1.6 |
Data are given in percentage injected dose per gram (%ID/g) and are mean ± SD. Data for 68Ga-PSMA-I&T from a previous publication (4) are included for comparison.