Table 2.

Paired t-test comparing change in PHQ-9 item means at 6 and 18 months.

		Frequency (%)			Change T1 to T3a
During the past 2 weeks how often have you been bothered by any of the following problems:	Months post diagnosis	Never	Several Days	> ½ or nearly every dayb	t (1,121)	p
1. Little interest or pleasure in doing things	6 12 18	66.7 70.0 63.4	16.3 17.1 20.3	17.1 12.5 16.3	−0.39	.699
2. Feel down, depressed or hopeless	6 12 18	62.6 63.3 57.7	21.1 24.2 23.6	16.3 12.5 18.7	−0.90	.371
3. Trouble falling or staying asleep, or sleeping too much	6 12 18	48.8 59.2 52.8	16.3 13.3 18.7	35.0 27.5 28.5	1.86	.066
4. Feeling tired or having little energy	6 12 18	39.8 37.5 37.4	21.1 32.5 27.6	39.0 30.0 35.0	1.26	.210
5. Poor appetite or overeating	6 12 18	58.5 68.3 59.3	17.9 15.0 18.7	23.6 16.7 22.0	−0.15	.881
6. Feel bad about yourself – or that you are a failure or have let yourself or your family down	6 12 18	77.2 79.2 78.0	9.8 12.5 12.2	13.0   8.3   9.8	1.05	.295
7. Trouble concentrating on things, such as reading the newspaper or watching television	6 12 18	72.4 70.8 69.9	13.8 15.8 17.1	13.8 13.3 13.0	−0.32	.749
8. Moving or speaking so slowly that other people could have noticed. Or the opposite – being so fidgety or restless that you have been moving around a lot more than usual	6 12 18	72.4 69.2 72.4	13.0 18.3 15.4	14.6 12.5 12.2	0.53	.598
9. Thoughts that you would be better off dead, or of hurting yourself	6 12 18	89.3 96.7 88.5	5.7   1.7   9.0	4.9   1.7   2.5	0.15	.880

Note. PHQ-9 = Patient Health Questionnaire-9.

^aPaired t-test comparing 6 months mean to 18 months mean (items rated on 4 point scale).

^bThe categories of more than half of the days and nearly every day are combined in this table.