Table 1.
Comparison of ABW versus AdjBW groups.
| Variable | ABW group (n = 50) | AdjBW group (n = 51) | p value for difference |
|---|---|---|---|
| Age (years) | 51 (38–57) 20, 78 |
51 (44–59) 19, 76 |
0.401a |
| Males | 23 (46) | 26 (51) | 0.617b |
| Race | 0.014c | ||
| African American | 8 (16) | 2 (4) | |
| Hispanic | 1 (2) | 2 (4) | |
| Native American | 2 (4) | 0 (0) | |
| White | 34 (68) | 32 (63) | |
| Unknown/missing | 5 (10) | 15 (29) | |
| BMI category | 0.092b | ||
| Class I: (30.0–34.9 kg/m2) | 24 (48) | 14 (27) | |
| Class II: (35.0–39.9 kg/m2) | 11 (22) | 18 (35) | |
| Class III: (⩾40.0 kg/m2) | 15 (30) | 19 (37) | |
| BMI (kg/m2) | 35 (32–43) | 37 (34–43) | 0.187a |
| 30, 69 | 30, 61 | ||
| Length of stay (days) | 21 (10–39) | 25 (14–36) | 0.315a |
| 6, 88 | 3, 123 | ||
| Duration of therapy (days) | 8.0 (5.0–42.0) | 11.5 (5.0–29.0) | 0.563a |
| 3, 56 | 3, 56 | ||
| Indication | 0.593c | ||
| UTI | 5 (10) | 3 (5.8) | |
| SSTI | 8 (16) | 4 (7.8) | |
| Abscess | 6 (12) | 6 (11.8) | |
| Osteomyelitis | 20 (40) | 11 (21.6) | |
| Endocarditis | 0 (0) | 3 (6) | |
| Bacteremia | 3 (6) | 12 (23.5) | |
| Intra-abdominal infection | 4 (8) | 5 (9.8) | |
| Neutropenic fever | 3 (6) | 3 (6) | |
| Empiric | 1 (2) | 4 (7.8) | |
| Dose category prescribed (mg/kg) | ABW, n (%) | AdjBW, n (%) | |
| Low ⩽6 mg/kg/day 5.4 ± 0.8 mg/kg/d (mean ± standard deviation) |
41 (82) | 11 (22) | 0.001b |
| Medium 6.1–8.0 mg/kg/day 7.5 ± 0.6 mg/kg/d (mean ± standard deviation) |
7 (14) | 23 (45) | |
| High >8.0 mg/kg/day 8.9 ± 0.9 mg/kg/d (mean ± standard deviation) |
2 (4) | 17 (33) |
ABW: actual body weight; AdjBW: adjusted body weight; BMI: body mass index; SSTI: skin and soft tissue infection; UTI: urinary tract infection.
Values represent median (interquartile range) and minimum, maximum, or number (%).
a
Mann–Whitney U test.
b
Pearson’s chi-square.
c
Exact Pearson’s chi-square.