Figure 7.

FE rescues OP‐like symptom induced by Dex. (A), Alizarin red‐stained zebrafish head regions of FE‐treated larvae. 1 μg/mL FE‐added zebrafish totally recovers the stained signal strength in comparison with GIOP model (**P < .01) (D). (B), 3D‐reconstructed confocal images of FE‐treated Tg(ola.sp7:nlsGFP) zebrafish head regions. Bone mass and bone mineral density (BMD) evaluated by fluorescent area and IOD reflect a rescued effect on 1 μg/mL FE‐treated OP‐like zebrafish (**P < .01) (E, F). Data are presented as means ± SD; **P < .01; ***P < .001; n = 18 fish in each group; scale bar, 100 μm