Bryant 2018.

Methods	Randomisation Randomised controlled trial 2 arms: individualised prescriptive exercise intervention 2 to 4 times per week for a period of the induction chemotherapy/in‐hospital recovery vs usual care Recruitment period May 2014 to November 2015 Median follow‐up time 6 weeks Sample size calculation Not reported
Participants	Eligibility criteria Newly diagnosed with acute leukaemia by pathology report Admitted for induction chemotherapy within in the previous 96 hours or +/‐ 3 days from initiation of induction chemotherapy An expected hospital stay of 3 to 4 weeks or longer Participation in the study must be approved by the physician directly responsible for the patient's care Age ≥ 21 years Ability to speak and understand English Ability to use a computer No severe comorbidity that would not allow physical training Give written informed consent Participants (N = 17) Intervention group (N = 8) Control group (N = 9) Mean age Interventions group: 52 years Control group: 49 years Stage of disease Intervention group: not reported Control group: not reported Country USA
Interventions	Exercise group Individualised prescriptive exercise intervention 2 to 4 times per week for a period of the induction chemotherapy/in‐hospital recovery The exercise intervention began on week 1 of the study, the day after the first batteries of initial assessments were concluded Each exercise session was divided into two parts. One part was administered in the morning and the second one late in the afternoon. There was a period of rest of at least 36 hours between each exercise session Control group Standard care
Outcomes	Reported Anthropometric measurements Physical performance Fatigue Quality of sleep Anxiety Depression Quality of life Not reported but relevant Overall survival Reported but not relevant none Primary outcome Fatigue
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote:"The randomization sequence was generated by the study’s statistician. The statistician and research outcome assessors were blinded to the randomization allocation"
Allocation concealment (selection bias)	Low risk	Quote:"The randomization sequence was generated by the study’s statistician. The statistician and research outcome assessors were blinded to the randomization allocation"
Blinding of participants and personnel (performance bias) All outcomes	High risk	Blinding in this context is not feasible
Blinding of outcome assessor (primary endpoint; mortality)	Low risk	The review authors judge that the outcome mortality in this unblinded trial is unlikely to be influenced by lack of blinding
Blinding of outcome assessor (patient‐reported outcomes)	High risk	Blinding in this context is not feasible
Blinding of outcome assessor (physical performance, AEs, SAEs)	Unclear risk	Quote:"The randomization sequence was generated by the study’s statistician. The statistician and research outcome assessors were blinded to the randomization allocation"
Incomplete outcome data (attrition bias) All outcomes	High risk	Quote:"1 dropped before the intervention started" (intervention group)
Selective reporting (reporting bias)	Low risk	All outcomes mentioned in the protocol are reported
Other bias	Low risk	None