Table 2.
Bivariate associations between linear outcome (maximum creatinine during Day 2 and Day 3) and binary outcome (AKI) and Predictors
| Variable | Linear Regression | Logistic Regression | ||||
|---|---|---|---|---|---|---|
| Coeff | P-Value | 95% CI | OR | P-Value | 95% CI | |
| Gender | ||||||
| (M: 1,F: 0) | 0.2135 | < 0.001 | [0.206,0.221] | 1.23 | < 0.001 | [1.144,1.318] |
| Age (yr) | 0.0019 | < 0.001 | [0.002,0.002] | 1.02 | < 0.001 | [1.016,1.020] |
| Ethnicity | ||||||
| African-American | ref | ref | ref | ref | ref | ref |
| Caucasian | −0.0706 | < 0.001 | [−0.086,-0.055] | 1.12 | 0.106 | [0.976,1.294] |
| Hispanic | −0.1026 | < 0.001 | [− 0.128,-0.077] | 0.73 | 0.014 | [0.566,0.938] |
| Other | −0.0585 | < 0.001 | [− 0.076,-0.041] | 1.33 | < 0.001 | [1.136,1.552] |
| Systolic BP Min (mmHg) | −0.0011 | < 0.001 | [−0.001,-0.001] | 0.98 | < 0.001 | [0.976,0.980] |
| Systolic BP Mean (mmHg) | −0.0005 | < 0.001 | [−0.001,0.000] | 0.98 | < 0.001 | [0.982,0.987] |
| Diastolic BP Min (mmHg) | −0.0003 | 0.067 | [− 0.001,0.000] | 0.98 | < 0.001 | [0.980,0.986] |
| Diastolic BP Mean (mmHg) | −0.0009 | < 0.001 | [−0.001,0.001] | 0.98 | < 0.001 | [0.971,0.978] |
| Temperature Max (Celsius) | −0.0035 | 0.190 | [−0.009,0.002] | 1.04 | 0.089 | [0.994,1.089] |
| SpO2 Min (%) | −0.0014 | < 0.001 | [−0.002,-0.001] | 0.99 | < 0.001 | [0.983,0.991] |
| SpO2 Mean (%) | −0.0028 | 0.010 | [−0.005,-0.001] | 1.08 | < 0.001 | [1.055,1.098] |
| Bicarbonate Level Min (mg/dL) | −0.0049 | < 0.001 | [−0.006,-0.004] | 0.94 | < 0.001 | [0.934,0.949] |
| Creatinine Level Minimum (mg/dL) | 0.9479 | < 0.001 | [0.933,0.963] | – | – | – |
| Creatinine Level Max (mg/dL) | 0.9340 | < 0.001 | [0.921,0.947] | 3.20 | < 0.001 | [2.743, 3.737] |
| Hemoglobin Level Min (g/dL) | −0.0048 | < 0.001 | [− 0.007,-0.003] | 0.77 | < 0.001 | [0.759,0.787] |
| Platelet Count Min (K/μL) | − 0.0004 | < 0.001 | [− 0.000,0.000] | 1.00 | < 0.001 | [0.996,0.997] |
| Potassium Level Max (mg/dL) | 0.0837 | < 0.001 | [0.079,0.089] | 1.90 | < 0.001 | [1.824,1.984] |
| Partial Thromboplastin Time Min (s) | 0.0020 | < 0.001 | [0.002,0.002] | 1.01 | < 0.001 | [1.010,1.015] |
| Partial Thromboplastin Time Max (s) | 0.0012 | < 0.001 | [0.001,0.001] | 1.01 | < 0.001 | [1.008,1.010] |
| International Normalized Ratio Min | 0.0213 | < 0.001 | [0.013,0.030] | 1.04 | 0.266 | [0.970,1.118] |
| International Normalized Ratio Max | 0.0274 | < 0.001 | [0.022,0.033] | 1.21 | < 0.001 | [1.158,1.260] |
| Prothrombin Time Min (s) | 0.0032 | < 0.001 | [0.002,0.004] | 1.01 | 0.194 | [0.997,1.015] |
| Prothrombin Time Max (s) | 0.0042 | < 0.001 | [0.003,0.005] | 1.03 | < 0.001 | [1.021,1.033] |
| Blood Urea Nitrogen Level Max (mg/dL) | 0.0088 | < 0.001 | [0.008,0.009] | 1.01 | < 0.001 | [1.009,1.017] |
| White Blood Cell Count Max (K/μL) | 0.0008 | < 0.001 | [0.000,0.001] | 1.01 | < 0.001 | [1.010,1.018] |
| Calcium Level Min (mg/dL) | 0.0245 | < 0.001 | [0.019,0.030] | 0.72 | < 0.001 | [0.685,0.749] |
| Mechanical Ventilation (Yes 1/No 0) - N, % | 0.0618 | < 0.001 | [0.054,0.070] | 3.04 | < 0.001 | [2.816,3.275] |
| Estimated Glomerular Filtration Rate (eGFR) | −0.0025 | < 0.001 | [−0.003,-0.002] | 1.00 | < 0.001 | [1.004,1.005] |
CI denotes confidence interval, OR denotes odds ratio, Coeff denotes linear regression coefficient. The regression coefficient and odds ratio are unadjusted regression coefficient and odds ratio respectively