Table 3.

Fewer litters born to dams fed a high fat diet survived until 2 weeks of age

Outcome	LFD	HFD
First pregnancy
Litter survival (n)	9/14	2/14*
Pups per litter (n)	2.9 ± 0.6	4.0 ± 1.0
Male pups per litter (n)	1.4 ± 0.4	1.0 ± 1.0
Female pups per litter (n)	1.3 ± 0.4	3.0 ± 0.0
Second pregnancy
Litter survival (n)	7/8	2/8*
Pups per litter (n)	4.7 ± 0.6	3.5 ± 0.5
Male pups per litter (n)	1.9 ± 0.4	1.0 ± 0.0
Female pups per litter (n)	2.9 ± 0.5	2.5 ± 0.5

*p < 0.05, compared with dams fed a LFD (using Fisher’s; Exact Test)

From 4 weeks of age, C57Bl/6 J female mice (n = 28) were separated into 2 treatment groups and fed either a low fat diet (LFD, n = 14) or high fat diet (HFD, n = 14). Female mice were first mated with C57Bl/6 J male mice after dams had been fed either diet for 12 weeks. Three weeks later, offspring were born. Dams were re-mated 1 week after their first litters were removed at 2 weeks of age. The numbers of offspring (male or female) per litter are reported for pups that survived until 2 weeks of age. Data are shown as mean ± SEM