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. 2019 Jan 31;18:18. doi: 10.1186/s12943-019-0948-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — LOXL4 expression is upregulated in HCC tissues and predicts a poor clinical outcome. a The mRNA expression level of LOXL4 in HCC tissues compared with the normal liver tissues (N) revealed using the GSE6764 dataset. b-c The mRNA expression level of LOXL4 in the non-tumorous liver (NT) and HCC tissues revealed using the GSE36376 (b) and GSE84402 (c) datasets. d The mRNA expression level of LOXL4 in 42 matched NT and HCC tissues derived from Ren Ji cohort detected by qRT-PCR. e IHC staining performed using an antibody against LOXL4 and representative photographs of the LOXL4 staining in NT and HCC tissues. (Scale bar: 100 μm). f LOXL4 expression was upregulated in 175 HCC tissues compared with NT tissues (T > N). g Comparison of overall survival of HCC patients with different LOXL4 protein expression. h Comparison of disease-free survival of HCC patients with different LOXL4 protein expression. i Overall survival analysis of HCC patients in TCGA cohort. j-k Forest plot showing the association between LOXL4 expression and HCC survival using univariate (j) and multivariate (k) analyses. (HR, hazard ratio; CI, confidence interval)