Fig. 2.

TGF-β induces LOXL4 expression in HCC cells. a LOXL4 mRNA expression in HCC cells exposed to mock vehicle or TGF-β (5 ng/ml) for 12 h. b LOXL4 mRNA expression in HCC cells exposed to 21% O₂ (Normoxia) or 1% O₂ (Hypoxia) for 16 h. c LOXL4 protein expression in HCC cells exposed to mock vehicle or TGF-β (5 ng/ml) for 12 h. d LOXL4 protein expression in HCC cells exposed to normoxia (N) or hypoxia (H) for 16 h. e LOXL4 mRNA expression in Huh7 and Hep3B cells transfected with siRNAs targeting SMAD4 exposed to mock vehicle or TGF-β (5 ng/ml) for 12 h. f LOXL4 protein expression in Huh7 and Hep3B cells transfected with siRNAs targeting SMAD4 exposed to mock vehicle or TGF-β (5 ng/ml) for 12 h. (** P < 0.01)