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. 2019 Jan 31;18:18. doi: 10.1186/s12943-019-0948-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — LOXL4 promotes HCC migration and invasion in vitro and metastasis in vivo. a-b. Cell migration (a) and invasion (b) potential was determined in SK-Hep1 and SMMC-7721 cells transfected with LOXL4 or control vector according to Transwell assays. c-d. Cell migration (c) and invasion (d) potential was determined in Hep3B and Huh7 cells transfected with shLOXL4 or shcontrol according to Transwell assays. e Tumor number on the liver surface 6 weeks after LOXL4-overexpressing SK-Hep1 cells (LOXL4/SK-Hep1) and control cells (vector/SK-Hep1) were orthotopically inoculated into the left hepatic lobe of nude mice. f Representative photographs of hematoxylin and eosin (H&E) staining in liver tissues from mice orthotopically inoculated with LOXL4/SK-Hep1 and control cells. g Lung metastases 6 weeks after LOXL4/SK-Hep1 and control cells were intravenously injected into nude mice detected by H&E staining. (** P < 0.01) (Scale bar: a-d 100 μm, f-g 200 μm)